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学术报告:Next Generation Biomaterials and Accelerated Wound Repair

2017-11-07

主题:  Next Generation Biomaterials and Accelerated Wound Repair

主讲人:  Anthony S. Weiss地点:  松江校区图文信息中心第二报告厅时间:  2017-11-10 09:30:00组织单位:   化学化工与生物工程学院报告人简介:

Professor Weiss is the McCaughey Chair in Biochemistry, Professor of Biochemistry & Molecular Biotechnology, Leader of the Tissue Engineering & Regenerative Medicine Node at the Charles Perkins Centre, Distinguished Visiting Professor BK 21 Plus, and Professor at the Bosch Institute at the University of Sydney Australia. His awards include Fulbright Scholar, Innovator of Influence Award, Innovator of Influence Award, Innovator of Influence Award. He was recently President of the Matrix Biology Society, and is on the Global Executive of the Tissue Engineering and Regenerative Medicine International Society.

Professor Weiss is an innovator and founded the clinical stage company Elastagen Pty Ltd. He leads research on human tropoelastin and synthetic elastin, is an inventor on 42 awarded patents in 15 families, on 10 Editorial Boards, Fellow of the Royal Society of Chemistry, Fellow of the Australian Academy of Technological Sciences and Engineering, Fellow of the Royal Australian Chemical Institute, Fellow of the Royal Society of NSW, Fellow of the American Institute for Medical and Biological Engineering, Fellow of the Australian Institute of Company Directors, and Fellow of Biomaterials Science and Engineering.

内容简介:Tropoelastin contributes a physical role in elasticity and also substantially to the biology of repairing tissue. The emerging model from a range of our other collaborative in vivo studies is that tropoelastin encodes direct biological effects and has the versatility to promote tissue repair. We found that tropoelastin substantially improves healing by halving the time to repair full-thickness wounds in mice and pigs; tropoelastin elicits this response with early stage neo-angiogenesis, recruitment of mesenchymal stem cells and fibroblasts with enhanced repair in two weeks consistently in these small and large animals. We discovered that tropoelastin tightly controls vascular smooth muscle cell proliferation in neovessels following mouse implantation and sheep carotid interposition surgery. This potency is marked by the concerted appearance of blood vessels, neodermis and other tissues that work together to accelerate skin repair.

 

 

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